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CS-W001157 4
Total: USD 88.00

1-(Naphthalen-1-yl)urea

  • CAS No. 6950-84-1

  • Cat. No. CS-0466211
  • Purity≥98%
  • MDL No.MFCD00021444

*For research and further manufacturing use only, not for direct human use.

1-(Naphthalen-1-yl)urea|CS-0466211

Structure of 6950-84-1

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General Information

  • CAS No. 6950-84-1
  • Cat. No. CS-0466211
  • Purity ≥98%
  • MDL No. MFCD00021444
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀N₂O
  • Molecular Weight 186.21
  • Synonym(s) 1-Naphthylurea
  • SMILES NC(NC1=CC=CC2=CC=CC=C21)=O

Description

1-(Naphthalen-1-yl)urea features a rigid aromatic urea scaffold that enhances π-stacking interactions and hydrogen bonding capacity. This structure supports robust binding in supramolecular systems and serves as a key intermediate in the synthesis of functionalized heterocycles and bioactive compounds.

Application

1-(Naphthalen-1-yl)urea serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive urea derivatives through standard coupling protocols. Its naphthyl moiety imparts enhanced π-stacking and lipophilic character, while the urea group offers hydrogen-bonding capacity and metabolic stability. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns targeting kinase inhibitors and other target-directed scaffolds.

Synthesis

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      1-(Naphthalen-1-yl)urea|CS-0466211
      6950-84-1

    References

    • Walther; Wlodkowski Journal fuer Praktische Chemie (Leipzig), 1899 , vol. <2> 59, p. 269
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      917-61-3
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      134-32-7
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      1-(Naphthalen-1-yl)urea|CS-0466211
      6950-84-1

    References

    • Azam, Faizul; El-Gnidi, Bashir A.; Alkskas, Ismail A. European Journal of Medicinal Chemistry, 2010 , vol. 45, # 7 p. 2817 - 2826
  • Route3
    • null|null
      134-32-7
    • In-stock
      Urea|CS-B1800
      57-13-6
    • ~%
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      1-(Naphthalen-1-yl)urea|CS-0466211
      6950-84-1
    • 1,3-Di(naphthalen-1-yl)urea|CS-0902648
      607-56-7

    References

    • Pagliani Gazzetta Chimica Italiana, 1879 , vol. 9, p. 30 Chemische Berichte, 1879 , vol. 12, p. 385

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 1652
Class : 6.1
Packing Group : Ⅱ
Hazard Statements : H301
Precautionary Statements : P264-P270-P301+P310-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   2.3304
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

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