Di(prop-2-yn-1-yl)amine

Name: Di(prop-2-yn-1-yl)amine
Brand: ChemScene
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CAS No. 6921-28-4
Cat. No. CS-0199462
Purity≥97%
MDL No.MFCD00008574

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Structure of 6921-28-4

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General Information

CAS No. 6921-28-4
Cat. No. CS-0199462
Purity ≥97%
MDL No. MFCD00008574
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇N
Molecular Weight 93.13
Synonym(s) N-2-Propynyl-2-propyn-1-amine
SMILES C#CCNCC#C

Description

Di(prop-2-yn-1-yl)amine features two prop-2-yn-1-yl groups attached to a nitrogen center, delivering high reactivity in click chemistry and conjugation workflows. This terminal alkyne functionality enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC), facilitating site-specific labeling and bioconjugation. The molecule exhibits excellent stability under standard bench conditions and integrates readily into peptide and small-molecule scaffolds.

Application

Di(prop-2-yn-1-yl)amine serves as a versatile bifunctional building block for click chemistry and heterocycle synthesis. The terminal alkyne groups enable efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the secondary amine functions as a nucleophilic handle in conjugate additions or reductive amination. Its bench-stable, crystalline form facilitates handling and purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and materials science applications.

Synthesis

Route1
- 106-96-7
- ~%
- In-stock
  
  6921-28-4
- In-stock
  
  6921-29-5
References
- Annales de Chimie (Cachan, France), , vol. <13>1, p. 161,184,186
Route2
- 624-65-7
- 2450-71-7
- ~%
- In-stock
  
  6921-28-4
References
- Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 15, p. 133 - 140

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02,GHS05
Signal Word : Danger	UN#: 2734
Class : 8 (3)	Packing Group : Ⅱ
Hazard Statements : H226-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

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Computational Chemistry Data

TPSA 12.03
LogP -0.1576
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Fatty chain compounds

Building Blocks Functional Group Amine

Building Blocks Functional Group Alkyne

Chemical Biology Conjugation Chemistry/Click Chemistry Terminal Alkynes

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry Terminal Alkynes

Key Words

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Di(prop-2-yn-1-yl)amine

CAS No. 6921-28-4

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