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Structure of 6905-05-1
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1-(Bromomethyl)-4-fluoronaphthalene is a fluorinated naphthalene derivative featuring a bromomethyl group at the 1-position, enabling direct functionalization in cross-coupling and nucleophilic substitution reactions. The para-fluoro substituent enhances electron deficiency, improving reactivity in palladium-catalyzed transformations. This bench-stable, moisture-tolerant reagent integrates efficiently into complex molecular architectures for pharmaceutical and materials synthesis.
1-(Bromomethyl)-4-fluoronaphthalene serves as a versatile bifunctional building block for C–C and C–heteroatom coupling reactions. The bromomethyl group enables palladium-catalyzed cross-coupling with arylboranes, amines, and nucleophiles, while the fluorinated naphthalene core provides metabolic stability and enhanced lipophilicity. Its bench-stable solid form facilitates handling and purification, making it suitable for medicinal chemistry lead optimization and API intermediate synthesis.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H314
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Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501
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Lot numbers can be found on the outside label of a product: