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CS-W001157 4
Total: USD 88.00

1-(Bromomethyl)-4-fluoronaphthalene

  • CAS No. 6905-05-1

  • Cat. No. CS-0466196
  • Purity≥96%
  • MDL No.MFCD12025245
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(Bromomethyl)-4-fluoronaphthalene|CS-0466196

Structure of 6905-05-1

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Description

1-(Bromomethyl)-4-fluoronaphthalene is a fluorinated naphthalene derivative featuring a bromomethyl group at the 1-position, enabling direct functionalization in cross-coupling and nucleophilic substitution reactions. The para-fluoro substituent enhances electron deficiency, improving reactivity in palladium-catalyzed transformations. This bench-stable, moisture-tolerant reagent integrates efficiently into complex molecular architectures for pharmaceutical and materials synthesis.

Application

1-(Bromomethyl)-4-fluoronaphthalene serves as a versatile bifunctional building block for C–C and C–heteroatom coupling reactions. The bromomethyl group enables palladium-catalyzed cross-coupling with arylboranes, amines, and nucleophiles, while the fluorinated naphthalene core provides metabolic stability and enhanced lipophilicity. Its bench-stable solid form facilitates handling and purification, making it suitable for medicinal chemistry lead optimization and API intermediate synthesis.

General Information

  • CAS No. 6905-05-1
  • Cat. No. CS-0466196
  • Purity ≥96%
  • MDL No. MFCD12025245
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₈BrF
  • Molecular Weight 239.08
  • Synonym(s) 1-(broMoMethyl)-4-fluoro-1-naphthalene
  • SMILES C1=CC=C2C(=C1)C(=CC=C2F)CBr

Computational Chemistry Data

  • TPSA   0
  • LogP   3.8738
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group :
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

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