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CS-W001157 4
Total: USD 88.00

1-Chloro-2,7-naphthyridine

  • CAS No. 69042-30-4

  • Cat. No. CS-M0450
  • Purity≥95%
  • MDL No.MFCD00234389

*For research and further manufacturing use only, not for direct human use.

1-Chloro-2,7-naphthyridine|CS-M0450

Structure of 69042-30-4

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General Information

  • CAS No. 69042-30-4
  • Cat. No. CS-M0450
  • Purity ≥95%
  • MDL No. MFCD00234389
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClN₂
  • Molecular Weight 164.59
  • Synonym(s) 2,7-Naphthyridine, 1-Chloro-
  • SMILES ClC1=NC=CC2=C1C=NC=C2

Description

1-Chloro-2,7-naphthyridine is a heterocyclic electrophile featuring a chlorine atom at the 1-position and a nitrogen-rich core enabling selective coupling reactions. This bench-stable compound integrates readily into transition-metal-catalyzed transformations, serving as a key scaffold for constructing functionalized polycyclic systems in medicinal chemistry and materials science.

Application

1-Chloro-2,7-naphthyridine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions with broad functional group tolerance. Its electron-deficient naphthyridine core facilitates nucleophilic substitution and transition-metal-mediated transformations, making it valuable for constructing pharmaceutical scaffolds and advanced materials. The compound exhibits good bench stability and is readily purified by standard chromatographic methods.

Synthesis

  • Route1
    • 2,7-Naphthyridin-1(2h)-one hydrobromide|CS-0679663
      950746-19-7
    • ~%
    • In-stock
      1-Chloro-2,7-naphthyridine|CS-M0450
      69042-30-4

    References

    • US2009/221828 A1, ; Page/Page column 6-7 ;
  • Route2
    • 2,7-Naphthyridin-1-ol hydrochloride|CS-0268600
      369648-60-2
    • ~82%
    • In-stock
      1-Chloro-2,7-naphthyridine|CS-M0450
      69042-30-4

    References

    • CELLTECH R and D LIMITED Patent: WO2004/7428 A1, 2004 ; Location in patent: Page 44 ;
  • Route3
    • null|null
      950746-11-9
    • ~12%
    • In-stock
      1-Chloro-2,7-naphthyridine|CS-M0450
      69042-30-4

    References

    • UCB PHARMA, S.A. Patent: US2009/221828 A1, 2009 ; Location in patent: Page/Page column 8 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.2832
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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