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(R)-1-Pyrrolidin-2-ylmethanol

  • CAS No. 68832-13-3

  • Cat. No. CS-D1509
  • Purity≥96%
  • MDL No.MFCD00064321

*For research and further manufacturing use only, not for direct human use.

(R)-1-Pyrrolidin-2-ylmethanol|CS-D1509

Structure of 68832-13-3

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General Information

  • CAS No. 68832-13-3
  • Cat. No. CS-D1509
  • Purity ≥96%
  • MDL No. MFCD00064321
  • Storage RT, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁NO
  • Molecular Weight 101.15
  • Synonym(s) (R)-Prolinol; (R)-Pyrrolidin-2-methanol; (R)-Pyrrolidin-2-ylmethanol; D-Prolinol; (R)-(-)-2-Pyrrolidinemethanol
  • SMILES OC[C@@H]1NCCC1

Description

Versatile reagent for asymmetric synthesis.

Application

(R)-1-Pyrrolidin-2-ylmethanol serves as a versatile chiral building block in synthetic organic chemistry, enabling the construction of pyrrolidine-containing scaffolds common in medicinal chemistry. Its primary alcohol functionality facilitates efficient derivatization via esterification, ether formation, and oxidation to aldehydes. The molecule exhibits good bench stability and compatibility with standard protecting group strategies, supporting its use in multi-step syntheses requiring functional group tolerance and stereochemical integrity.

Synthesis

  • Route1

    References

    • US5130432 A1, ;
  • Route2

    References

    • Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), , p. 1149 - 1156
  • Route3

    References

    • Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), , p. 1149 - 1156

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   -0.2693
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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