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CS-W001157 4
Total: USD 88.00

2-[(Diphenylmethyl)thio]acetamide

  • CAS No. 68524-30-1

  • Cat. No. CS-W010281
  • Purity≥97%
  • MDL No.MFCD00876107

*For research and further manufacturing use only, not for direct human use.

2-[(Diphenylmethyl)thio]acetamide|CS-W010281

Structure of 68524-30-1

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General Information

  • CAS No. 68524-30-1
  • Cat. No. CS-W010281
  • Purity ≥97%
  • MDL No. MFCD00876107
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₅NOS
  • Molecular Weight 257.35
  • Synonym(s) None
  • SMILES O=C(CSC(C1=CC=CC=C1)C2=CC=CC=C2)N

Description

Potassium phenyl sulfate is the salt of gut metabolite phenol sulfate.It is biosynthesized from phenol and phosphoadenosine phosphosulfate through the action of the enzyme sulfotransferase 1A1 in the liver. Also, it induces reactive oxygen species (ROS) production and decreases glutathione levels, rendering cells vulnerable to oxidative stress.Metabolomics researchMicrobiome research

Application

2-[(Diphenylmethyl)thio]acetamide serves as a stable, bench-friendly thioether building block for the synthesis of sulfide-containing heterocycles and functionalized intermediates. Its diphenylmethyl (benzhydryl) group provides excellent protection for thiols under standard reaction conditions, enabling selective deprotection and subsequent transformations. The molecule facilitates efficient coupling reactions and exhibits good functional group tolerance, making it a practical choice in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • null|null
      90-99-3
    • In-stock
      2-Chloroacetamide|CS-W011345
      79-07-2
    • ~99%
    • In-stock
      2-[(Diphenylmethyl)thio]acetamide|CS-W010281
      68524-30-1

    References

    • PROCOS S.P.A. Patent: US2004/106829 A1, 2004 ; Location in patent: Page 3 ;
  • Route2
    • null|null
      121-44-8
    • null|null
      90-99-3
    • In-stock
      2-Chloroacetamide|CS-W011345
      79-07-2
    • ~82%
    • In-stock
      2-[(Diphenylmethyl)thio]acetamide|CS-W010281
      68524-30-1

    References

    • PROCOS S.P.A. Patent: US2004/106829 A1, 2004 ; Location in patent: Page 3 ;
  • Route3
    • null|null
      68524-29-8
    • ~98%
    • In-stock
      2-[(Diphenylmethyl)thio]acetamide|CS-W010281
      68524-30-1

    References

    • Olivo, Horacio F.; Osorio-Lozada, Antonio; Peeples, Tonya L. Tetrahedron Asymmetry, 2005 , vol. 16, # 21 p. 3507 - 3511

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07,GHS09
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335-H411
Precautionary Statements : P261-P264-P271-P273-P280-P302+P352-P304+P340-P362+P364-P391-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   3.24
  • LogP   3.6929
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   3

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