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CS-W001157 4
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7-Methoxy-1-tetralone

  • CAS No. 6836-19-7

  • Cat. No. CS-W001925
  • Purity≥98%
  • MDL No.MFCD00001696

*For research and further manufacturing use only, not for direct human use.

7-Methoxy-1-tetralone|CS-W001925

Structure of 6836-19-7

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General Information

  • CAS No. 6836-19-7
  • Cat. No. CS-W001925
  • Purity ≥98%
  • MDL No. MFCD00001696
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₂O₂
  • Molecular Weight 176.21
  • Synonym(s) None
  • SMILES O=C(CCC1)C2=C1C=CC(OC)=C2

Description

7-Methoxy-1-tetralone is a bench-stable, electron-rich tetralin derivative featuring a ketone at C1 and a methoxy group at C7. This structural combination enhances solubility in organic solvents and provides a selective handle for downstream functionalization in synthetic medicinal chemistry.

Application

7-Methoxy-1-tetralone serves as a versatile intermediate in synthetic organic chemistry, enabling access to substituted tetralin scaffolds through standard reduction and functionalization protocols. Its methoxy group provides orthogonal reactivity for selective transformations, while the ketone functionality supports nucleophilic additions, enolizations, and coupling reactions. Bench-stable and amenable to purification via recrystallization or chromatography, it functions effectively in medicinal chemistry lead optimization and heterocyclic synthesis workflows.

Synthesis

  • Route1

    References

    • Vercouillie, Johnny; Abarbri, Mohamed; Parrain, Jean-Luc; Duchene, Alain; Thibonnet, Jerome Synthetic Communications, 2004 , vol. 34, # 20 p. 3751 - 3762
  • Route2

    References

    • Chorghade, Rajeev; Battilocchio, Claudio; Hawkins, Joel M.; Ley, Steven V. Organic Letters, 2013 , vol. 15, # 22 p. 5698 - 5701
  • Route3

    References

    • Tetrahedron Letters, , vol. 28, # 19 p. 2131 - 2132

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.2142
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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