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CS-W001157 4
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2,4-Dichloro-6-fluorobenzaldehyde

  • CAS No. 681435-09-6

  • Cat. No. CS-0186501
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-6-fluorobenzaldehyde|CS-0186501

Structure of 681435-09-6

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General Information

  • CAS No. 681435-09-6
  • Cat. No. CS-0186501
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃Cl₂FO
  • Molecular Weight 193.00
  • Synonym(s) 2,4-DICHLORO-7-FLUOROBENZALDEHYDE
  • SMILES C1=C(C=C(C(=C1Cl)C=O)F)Cl

Description

2,4-Dichloro-6-fluorobenzaldehyde features a highly electron-deficient aromatic ring stabilized by orthogonal halogen substituents. This combination enhances reactivity in nucleophilic addition and coupling processes. The aldehyde group enables direct functionalization or integration into complex molecular architectures under mild conditions. Bench-stable and moisture-tolerant, it serves as a key building block for pharmaceutical intermediates and agrochemicals.

Application

2,4-Dichloro-6-fluorobenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via nucleophilic addition and condensation reactions. Its electron-deficient aromatic core enhances reactivity in Suzuki-Miyaura coupling and imine formation, while the orthogonal halogen substituents allow for selective functionalization. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for scalable process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.945
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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