Diethyl 2,2-difluoromalonate

Name: Diethyl 2,2-difluoromalonate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 680-65-9
Cat. No. CS-0043634
Purity≥95%
MDL No.MFCD00221617

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 680-65-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 680-65-9
Cat. No. CS-0043634
Purity ≥95%
MDL No. MFCD00221617
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₀F₂O₄
Molecular Weight 196.15
Synonym(s) diethyl difluoropropanedioate
SMILES O=C(OCC)C(F)(F)C(OCC)=O

Description

Diethyl 2,2-difluoromalonate features a highly electron-deficient malonate core stabilized by two fluorine atoms at the central carbon. This bench-stable reagent enables direct fluorination in synthetic sequences, integrating readily into nucleophilic substitution and Michael addition cascades. Its moisture-tolerant profile simplifies handling under standard conditions.

Application

Diethyl 2,2-difluoromalonate serves as a versatile synthon in synthetic organic chemistry, enabling the introduction of geminal difluoride motifs into complex molecules. Its malonate core facilitates nucleophilic substitution and condensation reactions, while the electron-withdrawing difluoromethylene group enhances α-proton acidity and stabilizes enol intermediates. The compound exhibits good bench stability and compatibility with standard functional groups, making it ideal for constructing fluorinated building blocks in medicinal chemistry and agrochemical research.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS02,GHS06
Signal Word : Danger	UN#: 2810
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H225-H301-H315-H319-H335
Precautionary Statements : P210-P240-P241-P280-P370+P378

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 52.6
LogP 0.7479
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 4

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Ester

Material Science Polymer Materials Macromolecular Monomer

Key Words

Diethyl 2,2-difluoromalonate sigmaDiethyl 2,2-difluoromalonate manufacturerDiethyl 2,2-difluoromalonate priceDiethyl 2,2-difluoromalonate structureDiethyl 2,2-difluoromalonate SDSbuy Diethyl 2,2-difluoromalonateDiethyl 2,2-difluoromalonate supplierDiethyl 2,2-difluoromalonate usesDiethyl 2,2-difluoromalonate molecular weightprice of Diethyl 2,2-difluoromalonateDiethyl 2,2-difluoromalonate chemical name formula of Diethyl 2,2-difluoromalonate

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Diethyl 2,2-difluoromalonate

CAS No. 680-65-9

Recommended Products