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CS-W001157 4
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Methyl 5-formylthiophene-3-carboxylate

  • CAS No. 67808-66-6

  • Cat. No. CS-D0187
  • Purity≥95%
  • MDL No.MFCD01859945

*For research and further manufacturing use only, not for direct human use.

Methyl 5-formylthiophene-3-carboxylate|CS-D0187

Structure of 67808-66-6

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General Information

  • CAS No. 67808-66-6
  • Cat. No. CS-D0187
  • Purity ≥95%
  • MDL No. MFCD01859945
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆O₃S
  • Molecular Weight 170.19
  • Synonym(s) Methyl 2-formyl-4-thiophenecarboxylate
  • SMILES O=C(C1=CSC(C=O)=C1)OC

Description

Methyl 5-formylthiophene-3-carboxylate features a thiophene core bearing both formyl and ester functionalities, enabling direct incorporation into heterocyclic scaffolds. The electron-deficient thiophene ring facilitates cross-coupling reactions, while the formyl group supports nucleophilic additions and condensation chemistries. This bifunctional reagent streamlines access to complex bioactive molecules under standard conditions.

Application

Methyl 5-formylthiophene-3-carboxylate serves as a versatile heterocyclic building block featuring orthogonal aldehyde and ester functionalities. The formyl group enables direct functionalization via nucleophilic additions, oxime formation, or reductive amination, while the ester supports hydrolysis, reduction, or coupling reactions. Its thiophene core provides structural rigidity and electronic modulation, making it suitable for synthesizing bioactive scaffolds in medicinal chemistry and materials science. The compound exhibits good bench stability and facilitates straightforward purification by column chromatography or recrystallization.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.37
  • LogP   1.3472
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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