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(R)-Pyrrolidine-2-carbonitrile hydrochloride

  • CAS No. 675602-84-3

  • Cat. No. CS-0053948
  • Purity≥97%
  • MDL No.MFCD03426407

*For research and further manufacturing use only, not for direct human use.

(R)-Pyrrolidine-2-carbonitrile hydrochloride|CS-0053948

Structure of 675602-84-3

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General Information

  • CAS No. 675602-84-3
  • Cat. No. CS-0053948
  • Purity ≥97%
  • MDL No. MFCD03426407
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉ClN₂
  • Molecular Weight 132.59
  • Synonym(s) 2-Pyrrolidinecarbonitrile,monohydrochloride, (2R)-
  • SMILES N#C[C@@H]1NCCC1.Cl

Description

(R)-Pyrrolidine-2-carbonitrile hydrochloride features a chiral pyrrolidine core bearing a nitrile group and a protonated amine, enabling efficient incorporation into asymmetric synthesis. This bench-stable salt delivers high reactivity in catalytic transformations and serves as a key scaffold for medicinal chemistry campaigns requiring stereocontrolled nitrogen heterocycles.

Application

(R)-Pyrrolidine-2-carbonitrile hydrochloride serves as a chiral building block for medicinal chemistry and catalytic synthesis, enabling efficient access to nitrogen-containing heterocycles. Its bench-stable form facilitates handling and purification, while the nitrile group supports diverse transformations including hydrolysis, reduction, and nucleophilic additions. Functions effectively in asymmetric synthesis and peptide backbone modification workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   35.82
  • LogP   0.68378
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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