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CS-W001157 4
Total: USD 88.00

2-Fluoro-6-hydroxybenzoic acid

  • CAS No. 67531-86-6

  • Cat. No. CS-W008162
  • Purity≥96%
  • MDL No.MFCD00052179

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-6-hydroxybenzoic acid|CS-W008162

Structure of 67531-86-6

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General Information

  • CAS No. 67531-86-6
  • Cat. No. CS-W008162
  • Purity ≥96%
  • MDL No. MFCD00052179
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅FO₃
  • Molecular Weight 156.11
  • Synonym(s) 6-Fluoro-2-hydroxybenzoic acid
  • SMILES O=C(O)C1=C(O)C=CC=C1F

Description

2-Fluoro-6-hydroxybenzoic acid features a strategically positioned fluorine atom and hydroxyl group on the aromatic ring, enabling enhanced metabolic stability and hydrogen bonding capacity. This combination supports efficient incorporation into bioactive scaffolds, particularly in kinase inhibitor design and medicinal chemistry lead optimization under standard conditions.

Application

2-Fluoro-6-hydroxybenzoic acid serves as a versatile building block for bioactive heterocycles and pharmaceutical intermediates, offering orthogonal reactivity between phenolic hydroxyl, carboxylic acid, and fluorine functional groups. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient derivatization in medicinal chemistry workflows.

Synthesis

  • Route1
    • 2-Fluoro-6-(methoxymethoxy)benzoic acid|CS-0196050
      368422-22-4
    • ~92%
    • In-stock
      2-Fluoro-6-hydroxybenzoic acid|CS-W008162
      67531-86-6

    References

    • Marzi, Elena; Mongin, Florence; Spitaleri, Andrea; Schlosser, Manfred European Journal of Organic Chemistry, 2001 , # 15 p. 2911 - 2915
  • Route2
    • null|null
      124-38-9
    • 1-Fluoro-3-(methoxymethoxy)benzene|CS-0150160
      126940-10-1
    • ~93%
    • In-stock
      2-Fluoro-6-hydroxybenzoic acid|CS-W008162
      67531-86-6

    References

    • Marzi, Elena; Bobbio, Carla; Cottet, Fabrice; Schlosser, Manfred European Journal of Organic Chemistry, 2005 , # 10 p. 2116 - 2123
  • Route3
    • null|null
      860296-18-0
    • null|null
      124-38-9
    • ~61%
    • In-stock
      2-Fluoro-6-hydroxybenzoic acid|CS-W008162
      67531-86-6

    References

    • Marzi, Elena; Bobbio, Carla; Cottet, Fabrice; Schlosser, Manfred European Journal of Organic Chemistry, 2005 , # 10 p. 2116 - 2123

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   1.2295
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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