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CS-W001157 4
Total: USD 88.00

5-Fluoropyrimidine

  • CAS No. 675-21-8

  • Cat. No. CS-W019203
  • Purity≥98%
  • MDL No.MFCD06658278

*For research and further manufacturing use only, not for direct human use.

5-Fluoropyrimidine|CS-W019203

Structure of 675-21-8

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General Information

  • CAS No. 675-21-8
  • Cat. No. CS-W019203
  • Purity ≥98%
  • MDL No. MFCD06658278
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃FN₂
  • Molecular Weight 98.08
  • Synonym(s) Pyrimidine, 5-fluoro-
  • SMILES FC1=CN=CN=C1

Description

5-Fluoropyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, offering enhanced metabolic stability and targeted electronic effects. This bench-stable compound integrates readily into nucleoside analogs and bioactive molecules, where its fluorinated ring system modulates reactivity and binding affinity.

Application

5-Fluoropyrimidine serves as a key building block in medicinal chemistry, enabling site-specific functionalization via nucleophilic substitution at the C5 position. Its high reactivity and bench stability facilitate efficient incorporation into heterocyclic scaffolds, including antiviral and anticancer agents. The fluorine atom enhances metabolic stability and modulates electronic properties, making it valuable for optimizing drug candidates through targeted derivatization.

Safety Information

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GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   0.6157
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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