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CS-W001157 4
Total: USD 88.00

4,6-Difluoropyrimidin-2-amine

  • CAS No. 675-11-6

  • Cat. No. CS-W022058
  • Purity≥97%
  • MDL No.MFCD00233527

*For research and further manufacturing use only, not for direct human use.

4,6-Difluoropyrimidin-2-amine|CS-W022058

Structure of 675-11-6

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General Information

  • CAS No. 675-11-6
  • Cat. No. CS-W022058
  • Purity ≥97%
  • MDL No. MFCD00233527
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₃F₂N₃
  • Molecular Weight 131.08
  • Synonym(s) 2-Amino-4,6-difluoropyrimidine
  • SMILES NC1=NC(F)=CC(F)=N1

Description

4,6-Difluoropyrimidin-2-amine features a highly reactive pyrimidine core with fluorine substituents at the 4 and 6 positions, enabling efficient coupling in nucleophilic substitution reactions. The amino group at position 2 provides a key handle for derivatization, particularly in medicinal chemistry applications. This compound serves as a critical building block for kinase inhibitors and other bioactive heterocycles due to its electron-deficient nature and favorable metabolic stability under standard conditions.

Application

4,6-Difluoropyrimidin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via nucleophilic substitution. Its difluoro substitution pattern enhances metabolic stability and modulates electronic properties, while the primary amine functionality facilitates coupling reactions. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for use in constructing heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.337
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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