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CS-W001157 4
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(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine

  • CAS No. 67496-29-1

  • Cat. No. CS-0157322
  • Purity≥95%
  • MDL No.MFCD11983446

*For research and further manufacturing use only, not for direct human use.

(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine|CS-0157322

Structure of 67496-29-1

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General Information

  • CAS No. 67496-29-1
  • Cat. No. CS-0157322
  • Purity ≥95%
  • MDL No. MFCD11983446
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BrNO₂
  • Molecular Weight 230.06
  • Synonym(s) None
  • SMILES C1=C(CN)C(=CC2=C1OCO2)Br

Description

This brominated benzodioxole methanamine integrates a reactive amine handle and electron-deficient aromatic core, enabling direct coupling in cross-coupling and bioconjugation workflows. The pendant amine facilitates derivatization under mild conditions, while the 6-bromo substituent supports palladium-catalyzed functionalization.

Application

(6-Bromobenzo[d][1,3]dioxol-5-yl)methanamine serves as a versatile building block for medicinal chemistry and materials synthesis, enabling efficient incorporation of brominated catechol motifs into target molecules. The primary amine functions as a handle for Suzuki-Miyaura coupling, reductive amination, or amide formation, while the 1,3-benzodioxole ring provides metabolic stability and favorable pharmacokinetic properties. Bench-stable and readily purified by standard chromatography, it facilitates scalable synthesis of bioactive heterocycles and functionalized aryl scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   44.48
  • LogP   1.6365
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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