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CS-W001157 4
Total: USD 88.00

SEP-227900

  • CAS No. 67268-37-5

  • Cat. No. CS-0071406
  • Purity≥98%
  • MDL No.MFCD07368660

*For research and further manufacturing use only, not for direct human use.

SEP-227900|CS-0071406

Structure of 67268-37-5

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General Information

  • CAS No. 67268-37-5
  • Cat. No. CS-0071406
  • Purity ≥98%
  • MDL No. MFCD07368660
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅NO₃
  • Molecular Weight 151.12
  • Synonym(s) None
  • SMILES O=C(C1=CC2=C(N1)C=CO2)O

Description

SEP-227900 is a bench-stable, moisture-tolerant reagent designed for efficient coupling in late-stage functionalization. This electron-deficient heterocycle integrates seamlessly into complex molecular architectures, offering high selectivity and compatibility with diverse reaction conditions.

Application

SEP-227900 serves as a robust building block for constructing biologically relevant heterocyclic scaffolds, featuring high bench stability and compatibility with standard coupling protocols. Its well-defined functional group tolerance enables reliable incorporation into complex molecular architectures, facilitating efficient synthesis of medicinally active compounds through established reaction pathways.

Synthesis

  • Route1

    References

    • Sparey, Tim; Abeywickrema, Pravien; Almond, Sarah; Brandon, Nick; Byrne, Noel; Campbell, Alister; Hutson, Pete H.; Jacobson, Marlene; Jones, Brian; Munshi, Sanjeev; Pascarella, Danette; Pike, Andrew; Prasad, G. Sridhar; Sachs, Nancy; Sakatis, Melanie; Sardana, Vinod; Venkatraman, Shankar; Young, Mary Beth Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3386 - 3391
  • Route2
    • Methyl 4H-furo[3,2-b]pyrrole-5-carboxylate|CS-0308336
      77484-99-2
    • ~%
    • In-stock
      SEP-227900|CS-0071406
      67268-37-5

    References

    • WO2010/17418 A1, ; Page/Page column 97 ; WO 2010/017418 A1
  • Route3
    • null|null
      1207616-85-0
    • ~%
    • In-stock
      SEP-227900|CS-0071406
      67268-37-5

    References

    • WO2010/17418 A1, ; Page/Page column 106; 142-143 ; WO 2010/017418 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.23
  • LogP   1.4591
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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