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Structure of 672-45-7
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6-(Trifluoromethyl)uracil integrates a strongly electron-withdrawing trifluoromethyl group at the C6 position of the uracil core, enhancing metabolic stability and altering hydrogen-bonding capacity. This modification imparts increased lipophilicity and resistance to enzymatic degradation, making it a valuable scaffold for probing nucleoside analog reactivity and developing targeted antimetabolite agents in medicinal chemistry workflows.
6-(Trifluoromethyl)uracil serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated nucleoside analogs through standard glycosylation protocols. Its trifluoromethyl group enhances metabolic stability and modulates electronic properties, while maintaining compatibility with common protecting group strategies. The compound exhibits good bench stability and facilitates efficient incorporation into heterocyclic scaffolds relevant to antiviral and anticancer research.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: