4-Amino-1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-iodopyrimidin-2(1H)-one

Name: 4-Amino-1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-iodopyrimidin-2(1H)-one
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 666848-11-9
Cat. No. CS-0160913
Purity≥97%
MDL No.MFCD09264239

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Amino-1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-iodopyrimidin-2(1H)-one|CS-0160913

Structure of 666848-11-9

Size

Price

Quantity

* Please select Quantity before adding items.

Description

This pyrimidinone derivative features a sterically shielded silyl-protected hydroxyl group and a reactive iodine at C5, enabling selective late-stage functionalization. The 4-amino substituent enhances electron density for coupling reactions, while the tetrahydrofuran ring imparts conformational rigidity. Designed for nucleoside analog synthesis, it offers improved stability and solubility under standard conditions.

Application

4-Amino-1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-iodopyrimidin-2(1H)-one serves as a key building block for nucleoside analog synthesis, enabling efficient late-stage functionalization in medicinal chemistry. The tert-butyldimethylsilyl (TBS) group provides robust protection of the hydroxyl moiety, offering excellent bench stability and compatibility with standard deprotection protocols. The iodopyrimidine core facilitates transition-metal-catalyzed cross-coupling reactions, while the amino and hydroxyl functionalities allow for orthogonal derivatization. This compound functions reliably in solid-phase synthesis and solution-phase assembly of complex heterocyclic scaffolds.

General Information

CAS No. 666848-11-9
Cat. No. CS-0160913
Purity ≥97%
MDL No. MFCD09264239
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₂₆IN₃O₄Si
Molecular Weight 467.37
Synonym(s) 5-TBDMS-5-I-2-dC
SMILES O[C@H]1C[C@H](N2C(N=C(N)C(I)=C2)=O)O[C@@H]1CO[Si](C)(C)C(C)(C)C

Computational Chemistry Data

TPSA 99.6
LogP 2.1003
H_Acceptors 7
H_Donors 2
Rotatable_Bonds 4

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Life Science Nucleosides & Nucleotides Nucleosides, Deoxyribonucleosides and Other Nucleosides

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleosides

Catalysis Compounds by Element Classes Metal Compounds Semimetal Compounds

Key Words

666848-11-9 sigma666848-11-9 manufacturer666848-11-9 price666848-11-9 structure666848-11-9 SDSbuy 666848-11-9666848-11-9 supplier666848-11-9 uses666848-11-9 molecular weightprice of 666848-11-9666848-11-9 chemical name formula of 666848-11-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Amino-1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-iodopyrimidin-2(1H)-one

CAS No. 666848-11-9

Recommended Products