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CS-W001157 4
Total: USD 88.00

2,3-Difluoro-1-methoxy-4-nitrobenzene

  • CAS No. 66684-59-1

  • Cat. No. CS-W006353
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,3-Difluoro-1-methoxy-4-nitrobenzene|CS-W006353

Structure of 66684-59-1

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General Information

  • CAS No. 66684-59-1
  • Cat. No. CS-W006353
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₂NO₃
  • Molecular Weight 189.12
  • Synonym(s) 2,3-Difluoro-4-nitroanisole
  • SMILES O=[N+](C1=CC=C(OC)C(F)=C1F)[O-]

Description

2,3-Difluoro-1-methoxy-4-nitrobenzene features a highly electron-deficient aromatic core with orthogonal fluorine and nitro substituents enabling selective coupling reactions. The methoxy group enhances solubility while maintaining stability under standard conditions. This scaffold integrates readily into complex molecular architectures requiring precise electronic tuning and steric control.

Synthesis

  • Route1

    References

    • Journal of Medicinal Chemistry, , vol. 37, # 9 p. 1362 - 1370

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   52.37
  • LogP   1.8816
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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