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CS-W001157 4
Total: USD 88.00

2,2-Dimethyl-3-phenylmethoxypropan-1-ol

  • CAS No. 66582-32-9

  • Cat. No. CS-0060977
  • Molecule weight194.27
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,2-Dimethyl-3-phenylmethoxypropan-1-ol|CS-0060977

Structure of 66582-32-9

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General Information

  • CAS No. 66582-32-9
  • Cat. No. CS-0060977
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₈O₂
  • Molecular Weight 194.27
  • Synonym(s) 3-(Benzyloxy)-2,2-dimethylpropan-1-ol
  • SMILES CC(C)(CO)COCC1=CC=CC=C1

Description

This bench-stable, moisture-tolerant alcohol features a sterically hindered tertiary carbon center flanked by a phenylmethoxy group and a dimethyl-substituted chain. The protected hydroxyl moiety enables selective functionalization in complex synthesis workflows.

Application

2,2-Dimethyl-3-phenylmethoxypropan-1-ol serves as a stable, bench-ready building block for the synthesis of chiral auxiliaries and functionalized heterocycles. Its tertiary alcohol functionality enables straightforward derivatization, while the benzyloxy group offers orthogonal protection compatibility. The molecule exhibits excellent functional group tolerance and facilitates efficient transformations in standard coupling and cyclization protocols, making it valuable for iterative synthetic sequences in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      100-39-0
    • null|null
      126-30-7
    • ~90%
    • In-stock
      2,2-Dimethyl-3-phenylmethoxypropan-1-ol|CS-0060977
      66582-32-9

    References

    • Maki, Toshihide; Ushijima, Nobuto; Matsumura, Yoshihiro; Onomura, Osamu Tetrahedron Letters, 2009 , vol. 50, # 13 p. 1466 - 1468
  • Route2
    • null|null
      100-44-7
    • null|null
      126-30-7
    • ~91%
    • In-stock
      2,2-Dimethyl-3-phenylmethoxypropan-1-ol|CS-0060977
      66582-32-9

    References

    • Kalesse, Markus; Quitschalle, Monika; Claus, Eckhard; Gerlach, Kai; Pahl, Axel; Meyer, Hartmut H. European Journal of Organic Chemistry, 1999 , # 11 p. 2817 - 2823
  • Route3
    • null|null
      776-88-5
    • ~92%
    • In-stock
      2,2-Dimethyl-3-phenylmethoxypropan-1-ol|CS-0060977
      66582-32-9

    References

    • Mukaiyama, Teruaki; Shiina, Isamu; Sakata, Kaku; Emura, Takayuki; Seto, Keitarou; Saitoh, Masahiro Chemistry Letters, 1995 , # 3 p. 179 - 180

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   2.2217
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   5

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