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CS-W001157 4
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4-(3-(Trifluoromethyl)phenyl)piperidine hydrochloride

  • CAS No. 6652-16-0

  • Cat. No. CS-0086829
  • Purity≥97%
  • MDL No.MFCD02178913

*For research and further manufacturing use only, not for direct human use.

4-(3-(Trifluoromethyl)phenyl)piperidine hydrochloride|CS-0086829

Structure of 6652-16-0

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General Information

  • CAS No. 6652-16-0
  • Cat. No. CS-0086829
  • Purity ≥97%
  • MDL No. MFCD02178913
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅ClF₃N
  • Molecular Weight 265.70
  • Synonym(s) 4-(3-Trifluoromethylphenyl)Piperidine Hydrochloride
  • SMILES FC(C1=CC(C2CCNCC2)=CC=C1)(F)F.[H]Cl

Description

4-(3-(Trifluoromethyl)phenyl)piperidine hydrochloride features a trifluoromethyl-substituted phenyl ring fused to a piperidine core, delivering enhanced lipophilicity and metabolic stability. This scaffold serves as a key building block in medicinal chemistry for CNS-targeted therapeutics, offering improved membrane permeability and target engagement under standard bench conditions.

Application

4-(3-(Trifluoromethyl)phenyl)piperidine hydrochloride serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive compounds through standard amine functionalization and coupling reactions. Its trifluoromethylated aryl group enhances metabolic stability and membrane permeability, while the piperidine core provides a rigid, basic nitrogen for hydrogen bonding and target engagement. The hydrochloride salt ensures excellent solubility and bench stability, facilitating straightforward handling and purification in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   3.5942
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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