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CS-W001157 4
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H-D-Lys(Boc)-OMe.HCl

  • CAS No. 66494-53-9

  • Cat. No. CS-0132094
  • Purity≥97%
  • MDL No.MFCD00180720

*For research and further manufacturing use only, not for direct human use.

H-D-Lys(Boc)-OMe.HCl|CS-0132094

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General Information

  • CAS No. 66494-53-9
  • Cat. No. CS-0132094
  • Purity ≥97%
  • MDL No. MFCD00180720
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₅ClN₂O₄
  • Molecular Weight 296.79
  • Synonym(s) H-D-LYS(BOC)-OME HCL
  • SMILES O=C(OC)[C@H](N)CCCCNC(OC(C)(C)C)=O.Cl

Description

H-D-Lys(Boc)-OMe.HCl features a protected D-lysine residue with a tert-butoxycarbonyl group and methyl ester terminus, enabling stable incorporation into peptide chains. This bench-stable derivative facilitates efficient synthesis of D-amino acid-containing peptides under standard coupling conditions.

Application

H-D-Lys(Boc)-OMe·HCl serves as a stable, bench-ready building block for the synthesis of D-lysine-containing peptides and peptidomimetics. The Boc group provides orthogonal protection for the α-amino function, while the methyl ester facilitates efficient coupling and subsequent hydrolysis. This derivative exhibits excellent functional group tolerance and simplifies purification in solid-phase and solution-phase peptide synthesis workflows.

Synthesis

  • Route1

    References

    • Chakravarty; Carl; Weber; Katzenellenbogen Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 633 - 638

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   90.65
  • LogP   1.6035
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   6

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