2-Chloro-4-methylphenol

Name: 2-Chloro-4-methylphenol
Brand: ChemScene
Availability: InStock
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CAS No. 6640-27-3
Cat. No. CS-W004089
Purity≥97%
MDL No.MFCD00070639

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 6640-27-3

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General Information

CAS No. 6640-27-3
Cat. No. CS-W004089
Purity ≥97%
MDL No. MFCD00070639
Storage RT, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇ClO
Molecular Weight None
Synonym(s) 2-chloro-4-methyl-pheno
SMILES CC1=CC(Cl)=C(O)C=C1

Description

2-Chloro-4-methylphenol delivers a strategically positioned chloro group and methyl substituent on the aromatic ring, enabling selective functionalization in synthetic pathways. This electron-deficient phenolic scaffold supports efficient coupling reactions and serves as a key intermediate in agrochemical and pharmaceutical synthesis.

Application

2-Chloro-4-methylphenol serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted aromatic scaffolds. Its ortho-chloro and para-methyl functionalities offer predictable reactivity in nucleophilic aromatic substitution and coupling processes. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for medicinal chemistry campaigns and process-scale synthesis.

Synthesis

Route1
- 106-44-5
- ~79%
- In-stock
  
  6640-27-3
References
- Mukhopadhyay, Sudip; Chandnani, Kavita H.; Chandalia, Sampatraj B. Organic Process Research and Development, 1999 , vol. 3, # 3 p. 196 - 200
Route2
- 106-44-5
- ~%
- 56180-49-5
- In-stock
  
  6640-27-3
References
- Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 385 - 392
Route3
- 106-44-5
- ~%
- 70264-59-4
- 56180-49-5
- In-stock
  
  6640-27-3
References
- Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 36, # 10 p. 675 - 684

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 20.23
LogP 2.35402
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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2-Chloro-4-methylphenol

CAS No. 6640-27-3

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