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CS-W001157 4
Total: USD 88.00

N-Phenylpyridin-2-amine

  • CAS No. 6631-37-4

  • Cat. No. CS-0095245
  • Purity≥98%
  • MDL No.MFCD00006248

*For research and further manufacturing use only, not for direct human use.

N-Phenylpyridin-2-amine|CS-0095245

Structure of 6631-37-4

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General Information

  • CAS No. 6631-37-4
  • Cat. No. CS-0095245
  • Purity ≥98%
  • MDL No. MFCD00006248
  • Storage RT, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀N₂
  • Molecular Weight 170.21
  • Synonym(s) phenyl-2-pyridiylamine
  • SMILES C1(NC2=CC=CC=C2)=NC=CC=C1

Description

N-Phenylpyridin-2-amine features a pyridine ring fused with an aniline moiety, delivering enhanced electron density at the nitrogen site. This structure enables robust coordination in transition metal catalysis and facilitates conjugation in organic electronic materials. The compound exhibits bench-stable handling under standard conditions and integrates readily into ligand frameworks for palladium-catalyzed cross-coupling reactions.

Application

N-Phenylpyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of biaryl scaffolds via palladium-catalyzed coupling reactions. Its pyridine nitrogen and aryl amine functionality provide orthogonal reactivity for sequential functionalization, while the stable, bench-ready structure facilitates purification and scalability in API development workflows.

Synthesis

  • Route1
    • null|null
      504-29-0
    • null|null
      108-86-1
    • ~83%
    • In-stock
      N-Phenylpyridin-2-amine|CS-0095245
      6631-37-4

    References

    • Liu, Yifeng; Bai, Yajun; Zhang, Juan; Li, Yangyang; Jiao, Junping; Qi, Xiaoli European Journal of Organic Chemistry, 2007 , # 36 p. 6084 - 6088
  • Route2
    • null|null
      504-29-0
    • In-stock
      Iodobenzene|CS-W008603
      591-50-4
    • ~84%
    • In-stock
      N-Phenylpyridin-2-amine|CS-0095245
      6631-37-4

    References

    • Quan, Zheng-Jun; Xia, Hai-Dong; Zhang, Zhang; Da, Yu-Xia; Wang, Xi-Cun Applied Organometallic Chemistry, 2014 , vol. 28, # 2 p. 81 - 85
  • Route3
    • null|null
      109-04-6
    • null|null
      74497-02-2
    • ~99%
    • In-stock
      N-Phenylpyridin-2-amine|CS-0095245
      6631-37-4

    References

    • Huang, Xiaomei; Xu, Shuguang; Tan, Qitao; Gao, Mingchun; Li, Minjie; Xu, Bin Chemical Communications, 2014 , vol. 50, # 12 p. 1465 - 1468

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   2.8252
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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