Beaucage reagent

Name: Beaucage reagent
Brand: ChemScene
Availability: InStock
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CAS No. 66304-01-6
Cat. No. CS-6141
Purity≥98%
MDL No.MFCD00132960

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

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Structure of 66304-01-6

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Description

Beaucage reagent delivers efficient phosphitylation under standard conditions, enabling rapid synthesis of phosphoramidite intermediates. This bench-stable reagent features a reactive phosphorus center paired with a protected nucleoside moiety, ensuring high coupling efficiency and minimal side reactions during oligonucleotide assembly workflows.

Application

Beaucage reagent serves as a reliable phosphitylating agent for the synthesis of oligonucleotides, enabling efficient 3′-O-phosphoramidite formation under mild conditions. Its bench-stable nature and high coupling efficiency facilitate reproducible solid-phase DNA/RNA synthesis, with excellent functional group tolerance and straightforward purification by standard chromatographic methods.

General Information

CAS No. 66304-01-6
Cat. No. CS-6141
Purity ≥98%
MDL No. MFCD00132960
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₄O₃S₂
Molecular Weight 200.24
Synonym(s) None
SMILES O=C(C1=CC=CC=C12)SS2(=O)=O

Computational Chemistry Data

TPSA 51.21
LogP 1.2623
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Sulfonate

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Chemical Biology Pharmaceutical Development and Drug Discovery Research Nucleic Acid Chemistry Phosphorylating Agents, Phosphorothioating Agents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Nucleic Acid Chemistry Sulfur Transfer Reagents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Nucleic Acid Chemistry Phosphorylating Agents, Phosphorothioating Agents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Nucleic Acid Chemistry Sulfur Transfer Reagents

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Beaucage reagent

CAS No. 66304-01-6

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