5-Chloro-2-nitroanisole

Name: 5-Chloro-2-nitroanisole
Brand: ChemScene
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CAS No. 6627-53-8
Cat. No. CS-W007477
Purity≥97%
MDL No.MFCD00007288

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Description

5-Chloro-2-nitroanisole features a chlorinated aromatic ring with complementary electron-withdrawing nitro and electron-donating methoxy groups, enabling selective cross-coupling reactions under standard conditions. This bench-stable derivative delivers precise regiocontrol in C–C bond formation, particularly valuable in medicinal chemistry scaffolds.

Application

5-Chloro-2-nitroanisole serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted heterocycles and aromatic scaffolds. Its ortho-nitro and para-chloro functionalities offer complementary reactivity for sequential functionalization—particularly in palladium-catalyzed coupling reactions and nucleophilic substitution processes. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for scalable synthesis workflows in API development.

General Information

CAS No. 6627-53-8
Cat. No. CS-W007477
Purity ≥97%
MDL No. MFCD00007288
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆ClNO₃
Molecular Weight 187.58
Synonym(s) 4-Chloro-2-methoxy-1-nitrobenzene
SMILES COC1=CC(Cl)=CC=C1[N+]([O-])=O

Computational Chemistry Data

TPSA 52.37
LogP 2.2568
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07,GHS08
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H350
Precautionary Statements : P264-P270-P280-P280

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Other Classifications

Building Blocks Functional Group Nitro compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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5-Chloro-2-nitroanisole

CAS No. 6627-53-8

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