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CS-W001157 4
Total: USD 88.00

tert-Butyl 4-(2-cyanoacetyl)piperidine-1-carboxylate

  • CAS No. 660406-84-8

  • Cat. No. CS-W001613
  • Purity≥97%
  • MDL No.MFCD08059465
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(2-cyanoacetyl)piperidine-1-carboxylate|CS-W001613

Structure of 660406-84-8

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Description

tert-Butyl 4-(2-cyanoacetyl)piperidine-1-carboxylate features a piperidine core functionalized with a cyanoacetyl group, enabling direct incorporation into heterocyclic scaffolds. The tert-butyl ester provides stability and ease of removal under mild acidic conditions, while the nitrile moiety serves as a key handle for downstream transformations such as Michael additions or cyclizations. This compound delivers a robust, moisture-tolerant platform for constructing complex nitrogen-containing architectures in medicinal chemistry and synthetic methodology development.

Application

tert-Butyl 4-(2-cyanoacetyl)piperidine-1-carboxylate serves as a versatile building block for heterocyclic synthesis, enabling efficient access to substituted piperidine scaffolds. The molecule combines a readily hydrolyzable tert-butyl ester with a reactive cyanoacetate moiety, facilitating transformations such as Michael additions, cyclizations, and subsequent functionalization. Its bench-stable nature and compatibility with standard purification protocols make it well-suited for iterative synthetic campaigns in medicinal chemistry and process development.

General Information

  • CAS No. 660406-84-8
  • Cat. No. CS-W001613
  • Purity ≥97%
  • MDL No. MFCD08059465
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₀N₂O₃
  • Molecular Weight 252.31
  • Synonym(s) None
  • SMILES N#CCC(=O)C1CCN(C(=O)OC(C)(C)C)CC1

Computational Chemistry Data

  • TPSA   70.4
  • LogP   2.11628
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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