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CS-W001157 4
Total: USD 88.00

5-Chloro-2-fluoro-4-iodopyridine

  • CAS No. 659731-48-3

  • Cat. No. CS-D0951
  • Purity≥98%
  • MDL No.MFCD04112566

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-fluoro-4-iodopyridine|CS-D0951

Structure of 659731-48-3

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General Information

  • CAS No. 659731-48-3
  • Cat. No. CS-D0951
  • Purity ≥98%
  • MDL No. MFCD04112566
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂ClFIN
  • Molecular Weight 257.43
  • Synonym(s) Pyridine, 5-chloro-2-fluoro-4-iodo-
  • SMILES IC1=CC(F)=NC=C1Cl

Description

5-Chloro-2-fluoro-4-iodopyridine is a trifunctional pyridine derivative featuring complementary halogen handles for cross-coupling reactions. The chlorine and fluorine substituents enable selective functionalization, while the iodine moiety serves as a high-reactivity partner in palladium-catalyzed transformations. This compound integrates readily into complex molecular architectures under standard conditions.

Application

5-Chloro-2-fluoro-4-iodopyridine serves as a versatile trifunctional pyridine building block for cross-coupling and heterocyclic synthesis. The strategically positioned chloro, fluoro, and iodo substituents enable sequential or selective transformations via palladium-catalyzed coupling, nucleophilic substitution, and electrophilic functionalization. Its bench-stable nature and orthogonal reactivity profile facilitate efficient access to complex pharmaceutical scaffolds and agrochemical intermediates.

Synthesis

  • Route1

    References

    • WO2007/16358 A1, ; Page/Page column 38 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.4787
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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