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CS-W001157 4
Total: USD 88.00

1-(4-Fluorophenyl)urea

  • CAS No. 659-30-3

  • Cat. No. CS-0454694
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(4-Fluorophenyl)urea|CS-0454694

Structure of 659-30-3

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General Information

  • CAS No. 659-30-3
  • Cat. No. CS-0454694
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FN₂O
  • Molecular Weight 154.14
  • Synonym(s) Urea, 1-(p-fluorophenyl)-
  • SMILES NC(NC1=CC=C(F)C=C1)=O

Description

1-(4-Fluorophenyl)urea features a fluorinated aromatic ring integrated with a urea linkage, delivering enhanced metabolic stability and targeted electronic properties. This bench-stable compound serves as a key scaffold in medicinal chemistry for designing kinase inhibitors and bioactive small molecules.

Application

1-(4-Fluorophenyl)urea serves as a versatile building block in medicinal chemistry, enabling the construction of urea-linked pharmacophores through standard coupling reactions. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient synthesis of targeted small molecules. The 4-fluorophenyl moiety enhances metabolic stability and modulates electronic properties, making it valuable for optimizing bioavailability in API development.

Synthesis

  • Route1
    • null|null
      917-61-3
    • null|null
      371-40-4
    • ~74%
    • In-stock
      1-(4-Fluorophenyl)urea|CS-0454694
      659-30-3

    References

    • Raja; Agarwal; Mahajan; Pandeya; Ananthan Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010 , vol. 49, # 10 p. 1384 - 1388
  • Route2
    • 3-Amino-1-(4-fluorophenyl)urea|CS-0225420
      153885-60-0
    • ~78%
    • In-stock
      1-(4-Fluorophenyl)urea|CS-0454694
      659-30-3

    References

    • Raja; Agarwal; Mahajan; Pandeya; Ananthan Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010 , vol. 49, # 10 p. 1384 - 1388
  • Route3
    • null|null
      352-33-0
    • ~%
    • In-stock
      1-(4-Fluorophenyl)urea|CS-0454694
      659-30-3

    References

    • Organic Letters, , vol. 13, # 12 p. 3262 - 3265

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H319
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   1.3163
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

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