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Structure of 659-28-9
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4-(Trifluoromethoxy)benzaldehyde features a para-trifluoromethoxy group that imparts high electron-withdrawal and enhanced metabolic stability. This aldehyde integrates readily into heterocyclic scaffolds and serves as a key building block in medicinal chemistry, particularly for kinase inhibitors and bioactive aromatic systems.
4-(Trifluoromethoxy)benzaldehyde serves as a versatile building block in medicinal chemistry and materials science, enabling efficient access to functionalized aromatics via standard coupling reactions. Its electron-withdrawing trifluoromethoxy group enhances metabolic stability and modulates lipophilicity, while the aldehyde functionality supports reliable transformations including Wittig reactions, reductive amination, and heterocycle synthesis. Bench-stable and readily purified by recrystallization, it functions effectively in multi-step syntheses requiring robust functional group compatibility.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: