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CS-W001157 4
Total: USD 88.00

2-Chlorobenzyl (2,5-dioxopyrrolidin-1-yl) carbonate

  • CAS No. 65853-65-8

  • Cat. No. CS-W010033
  • Purity≥97%
  • MDL No.MFCD00010743

*For research and further manufacturing use only, not for direct human use.

2-Chlorobenzyl (2,5-dioxopyrrolidin-1-yl) carbonate|CS-W010033

Structure of 65853-65-8

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General Information

  • CAS No. 65853-65-8
  • Cat. No. CS-W010033
  • Purity ≥97%
  • MDL No. MFCD00010743
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₀ClNO₅
  • Molecular Weight 283.66
  • Synonym(s) N-(2-Chlorobenzyloxycarbonyloxy)-succinimide
  • SMILES ClC1=C(COC(=O)ON2C(=O)CCC2=O)C=CC=C1

Description

N-Methylated pomalidomide is a ligand used as a negative control for pomalidomide (P0018) in the recruitment of the Cereblon (CRBN) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.

Synthesis

  • Route1

    References

    • Sawayama; Tsukamoto; Sasagawa; Nishimura; Deguchi; Takeyama; Hosoki Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 1 p. 110 - 115

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317-H319
Precautionary Statements : P261-P264-P272-P280-P302+P352-P362+P364-P501

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Computational Chemistry Data

  • TPSA   72.91
  • LogP   2.0572
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   3

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