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CS-W001157 4
Total: USD 88.00

5-Methylindoline

  • CAS No. 65826-95-1

  • Cat. No. CS-W013389
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Methylindoline|CS-W013389

Structure of 65826-95-1

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General Information

  • CAS No. 65826-95-1
  • Cat. No. CS-W013389
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁N
  • Molecular Weight 133.19
  • Synonym(s) 5-Methylindoline 5-methyl-2,3-dihydro-1H-indole in stock Factory
  • SMILES CC1=CC2=C(NCC2)C=C1

Description

5-Methylindoline is a bench-stable, electron-rich heterocycle featuring a methyl group at the 5-position of the indoline core. This substitution enhances solubility and modulates reactivity, enabling efficient incorporation into complex molecular architectures. The compound serves as a key scaffold in medicinal chemistry and materials science, offering improved stability and predictable coupling behavior under standard conditions.

Application

5-Methylindoline serves as a versatile building block in medicinal chemistry, offering a stable indoline core with enhanced lipophilicity due to the methyl substitution. It functions as a key scaffold for constructing bioactive molecules, particularly in kinase inhibitors and CNS-targeted therapeutics. The compound exhibits excellent bench stability, tolerates a range of functional groups, and participates reliably in standard coupling reactions, facilitating efficient synthesis of complex heterocyclic architectures.

Synthesis

  • Route1

    References

    • Kulkarni, Aditya; Zhou, Weihong; Toeroek, Bela Organic Letters, 2011 , vol. 13, # 19 p. 5124 - 5127
  • Route2
    • null|null
      500227-35-0
    • ~87%
    • In-stock
      5-Methylindoline|CS-W013389
      65826-95-1

    References

    • Rashatasakhon, Paitoon; Padwa, Albert Organic Letters, 2003 , vol. 5, # 2 p. 189 - 191
  • Route3
    • N-4-Methylphenylhydrazine|CS-0110658
      539-44-6
    • ~%
    • In-stock
      5-Methylindoline|CS-W013389
      65826-95-1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 6 p. 2167 - 2171

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.96302
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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