Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Chloro-6-methoxybenzonitrile

  • CAS No. 6575-10-6

  • Cat. No. CS-0131325
  • Purity≥98%
  • MDL No.MFCD00019743

*For research and further manufacturing use only, not for direct human use.

2-Chloro-6-methoxybenzonitrile|CS-0131325

Structure of 6575-10-6

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 6575-10-6
  • Cat. No. CS-0131325
  • Purity ≥98%
  • MDL No. MFCD00019743
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆ClNO
  • Molecular Weight 167.59
  • Synonym(s) None
  • SMILES N#CC1=C(OC)C=CC=C1Cl

Description

2-Chloro-6-methoxybenzonitrile features a strategically positioned nitrile group flanked by chlorine and methoxy substituents, enabling precise electronic tuning for cross-coupling reactions. This bench-stable, moisture-tolerant aryl building block integrates efficiently into pharmaceutical intermediates and functional materials, offering enhanced reactivity in palladium-catalyzed transformations under standard conditions.

Application

2-Chloro-6-methoxybenzonitrile serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted benzimidazoles, quinolines, and other heterocyclic scaffolds via nucleophilic aromatic substitution or palladium-catalyzed coupling. Its ortho-chloro and para-methoxy substituents provide complementary reactivity and electronic modulation, while the nitrile group offers a robust handle for further functionalization. The compound exhibits good bench stability and is readily purified by recrystallization or column chromatography, making it well-suited for high-throughput screening and process development workflows.

Synthesis

  • Route1

    References

    • SmithKline Beecham Corporation Patent: US6294531 B1, 2001 ;
  • Route2
    • 1-Chloro-3-methoxy-2-nitrobenzene|CS-0137632
      5472-99-1
    • ~%
    • In-stock
      2-Chloro-6-methoxybenzonitrile|CS-0131325
      6575-10-6

    References

    • Journal of the Chemical Society, , p. 192 Journal of the Chemical Society, , p. 2918,2923
  • Route3

    References

    • Journal of the Chemical Society, , p. 192 Journal of the Chemical Society, , p. 2918,2923

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   33.02
  • LogP   2.22028
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-Chloro-6-methoxybenzonitrile sigma2-Chloro-6-methoxybenzonitrile manufacturer2-Chloro-6-methoxybenzonitrile price2-Chloro-6-methoxybenzonitrile structure2-Chloro-6-methoxybenzonitrile SDSbuy 2-Chloro-6-methoxybenzonitrile2-Chloro-6-methoxybenzonitrile supplier2-Chloro-6-methoxybenzonitrile uses2-Chloro-6-methoxybenzonitrile molecular weightprice of 2-Chloro-6-methoxybenzonitrile2-Chloro-6-methoxybenzonitrile chemical name formula of 2-Chloro-6-methoxybenzonitrile
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label