Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

3,5-Dichlorobenzonitrile

  • CAS No. 6575-00-4

  • Cat. No. CS-W017636
  • Purity≥98%
  • MDL No.MFCD00001800

*For research and further manufacturing use only, not for direct human use.

3,5-Dichlorobenzonitrile|CS-W017636

Structure of 6575-00-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 6575-00-4
  • Cat. No. CS-W017636
  • Purity ≥98%
  • MDL No. MFCD00001800
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃Cl₂N
  • Molecular Weight 172.01
  • Synonym(s) Benzonitrile, 3,5-dichloro-
  • SMILES N#CC1=CC(Cl)=CC(Cl)=C1

Description

3,5-Dichlorobenzonitrile features a benzonitrile core substituted with chlorine atoms at the 3 and 5 positions, delivering enhanced electron-withdrawal and steric shielding. This configuration imparts stability and facilitates selective functionalization in cross-coupling reactions. The nitrile group enables downstream derivatization to carboxylic acids or amides, making this compound a valuable scaffold for medicinal chemistry and materials synthesis under standard conditions.

Application

3,5-Dichlorobenzonitrile serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted aromatic scaffolds. Its dual electron-withdrawing chloro groups enhance electrophilicity at the ring, facilitating nucleophilic aromatic substitution and transition-metal-catalyzed coupling reactions. The nitrile functionality provides a handle for downstream transformations, including hydrolysis to carboxylic acids or reduction to primary amines. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows.

Synthesis

  • Route1

    References

    • Ishii, Genki; Harigae, Ryo; Moriyama, Katsuhiko; Togo, Hideo Tetrahedron, 2013 , vol. 69, # 5 p. 1462 - 1469
  • Route2
    • null|null
      557-21-1
    • In-stock
      3,5-Dichlorophenylboronic acid|CS-D1010
      67492-50-6
    • ~69%
    • In-stock
      3,5-Dichlorobenzonitrile|CS-W017636
      6575-00-4

    References

    • Liskey, Carl W.; Liao, Xuebin; Hartwig, John F. Journal of the American Chemical Society, 2010 , vol. 132, # 33 p. 11389 - 11391
  • Route3
    • null|null
      626-43-7
    • ~%
    • In-stock
      3,5-Dichlorobenzonitrile|CS-W017636
      6575-00-4

    References

    • Justus Liebigs Annalen der Chemie, , vol. 269, p. 231

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   23.79
  • LogP   2.86508
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 3,5-Dichlorobenzonitrile sigma3,5-Dichlorobenzonitrile manufacturer3,5-Dichlorobenzonitrile price3,5-Dichlorobenzonitrile structure3,5-Dichlorobenzonitrile SDSbuy 3,5-Dichlorobenzonitrile3,5-Dichlorobenzonitrile supplier3,5-Dichlorobenzonitrile uses3,5-Dichlorobenzonitrile molecular weightprice of 3,5-Dichlorobenzonitrile3,5-Dichlorobenzonitrile chemical name formula of 3,5-Dichlorobenzonitrile
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label