Lot numbers can be found on the outside label of a product:
(1H-Benzo[d]imidazol-4-yl)methanol
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CAS No. 65658-13-1
- Cat. No. CS-0052551
- Purity≥95%
- MDL No.MFCD15144561
*For research and further manufacturing use only, not for direct human use.
![(1H-Benzo[d]imidazol-4-yl)methanol|CS-0052551](https://file.chemscene.com/productPIC/CS-0052551.gif)
Structure of 65658-13-1
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General Information
- CAS No. 65658-13-1
- Cat. No. CS-0052551
- Purity ≥95%
- MDL No. MFCD15144561
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₈N₂O
- Molecular Weight 148.16
- Synonym(s) 1H-Benzimidazol-4-ylmethanol
- SMILES OCC1=C2N=CNC2=CC=C1
Description
(1H-Benzo[d]imidazol-4-yl)methanol features a benzimidazole core with a strategically positioned hydroxymethyl group, enabling facile functionalization in medicinal chemistry. This bench-stable scaffold integrates readily into bioactive molecules, offering enhanced solubility and hydrogen-bonding capacity for targeted ligand design.
Application
(1H-Benzo[d]imidazol-4-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient access to biologically relevant heterocyclic scaffolds. Its benzimidazole core provides structural rigidity and hydrogen-bonding capacity, while the pendant alcohol facilitates derivatization via oxidation, esterification, or ether formation. The compound exhibits good bench stability and compatibility with standard purification protocols, making it well-suited for use in iterative synthesis campaigns targeting kinase inhibitors and other bioactive molecules.
Synthesis
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Route1
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In-stock
![Methyl 1H-benzo[d]imidazole-7-carboxylate|CS-0007685](https://file.chemscene.com/productPIC/CS-0007685.gif)
37619-25-3 - ~71%
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In-stock
65658-13-1
References
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NOVARTIS AG; BERST, Frederic; FURET, Pascal; MARZINZIK, Andreas Patent: WO2011/157787 A1, 2011 ; Location in patent: Page/Page column 71-72 ; WO 2011/157787 A1
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Route2
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In-stock
![1H-benzo[d]imidazole-4-carboxylic acid|CS-D0827](https://file.chemscene.com/productPIC/CS-D0827.gif)
46006-36-4 - ~59%
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In-stock
65658-13-1
References
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SIGNAL PHARMACEUTICALS, LLC Patent: WO2008/51494 A1, 2008 ; Location in patent: Page/Page column 132 ;
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Route3
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![Ethyl 1H-benzo[d]imidazole-7-carboxylate|CS-0042869](https://file.chemscene.com/productPIC/CS-0042869.gif)
167487-83-4 - ~90%
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In-stock
65658-13-1
References
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Deghati, Paymaneh Y. F.; Borghini, Alice; Van Den Nieuwendijk, Adrianus M. C. H.; Dissen-de Groote, Miriam; IJzerman, Adriaan P. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 6 p. 899 - 908
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Safety Information
Download SDS|
GHS Pictogram :
N/A
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GHS No : N/A
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Signal Word : N/A
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : N/A
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Precautionary Statements : N/A
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Quality Control
Computational Chemistry Data
- TPSA 48.91
- LogP 1.0552
- H_Acceptors 2
- H_Donors 2
- Rotatable_Bonds 1
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Key Words
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