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CS-W001157 4
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Morpholino(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone

  • CAS No. 656239-38-2

  • Cat. No. CS-0128867
  • Purity≥98%
  • MDL No.MFCD05863913
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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Morpholino(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone|CS-0128867

Structure of 656239-38-2

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Description

Morpholino(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone delivers a boronate-functionalized aryl scaffold with enhanced stability and solubility. This bench-stable reagent integrates seamlessly into Suzuki-Miyaura coupling workflows, enabling efficient C–C bond formation under mild conditions. The morpholino group improves polarity and handling, while the tetramethylboronate moiety ensures high reactivity and compatibility with diverse transition metal catalysts.

Application

Morpholino(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone serves as a versatile boronate building block for Suzuki-Miyaura cross-coupling reactions. The morpholinoacetophenone moiety provides enhanced solubility and stability, while the pinacol boronate group enables efficient coupling under mild conditions. This reagent facilitates the construction of biaryl scaffolds with high functional group tolerance and is well-suited for iterative synthesis in medicinal chemistry and process development workflows.

General Information

  • CAS No. 656239-38-2
  • Cat. No. CS-0128867
  • Purity ≥98%
  • MDL No. MFCD05863913
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₄BNO₄
  • Molecular Weight 317.19
  • Synonym(s) 4-(4-Morpholinylcarbonyl)Benzeneboronic Acid Pinacol Ester
  • SMILES O=C(N1CCOCC1)C2=CC=C(B3OC(C)(C)C(C)(C)O3)C=C2

Computational Chemistry Data

  • TPSA   48
  • LogP   1.4582
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P233-P261-P264-P271-P280-P302+P352-P304+P340-P330-P362-P501

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