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CS-W001157 4
Total: USD 88.00

2-Bromo-2'-fluoroacetophenone

  • CAS No. 655-15-2

  • Cat. No. CS-W004082
  • Purity≥96%
  • MDL No.MFCD00278796

*For research and further manufacturing use only, not for direct human use.

2-Bromo-2'-fluoroacetophenone|CS-W004082

Structure of 655-15-2

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General Information

  • CAS No. 655-15-2
  • Cat. No. CS-W004082
  • Purity ≥96%
  • MDL No. MFCD00278796
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrFO
  • Molecular Weight 217.04
  • Synonym(s) None
  • SMILES BrCC(C1=CC=CC=C1F)=O

Description

2-Bromo-2'-fluoroacetophenone features a strategically positioned bromine and fluorine at the ortho and para positions relative to the acetyl group, enhancing electrophilicity and enabling selective transformations. This electron-deficient aryl ketone integrates readily into cross-coupling reactions and serves as a key intermediate in synthesizing functionalized aromatic compounds under standard conditions.

Synthesis

  • Route1

    References

    • US2009/156642 A1, ; Page/Page column 40 ;
  • Route2
    • 1-(Bromoethynyl)-2-fluorobenzene|CS-0432678
      1246224-44-1
    • ~81%
    • In-stock
      2-Bromo-2'-fluoroacetophenone|CS-W004082
      655-15-2

    References

    • Tetrahedron Letters, , vol. 55, # 7 p. 1373 - 1375
  • Route3
    • 2-Fluoro-1-phenylethanone|CS-0037091
      450-95-3
    • ~%
    • In-stock
      2-Bromo-2'-fluoroacetophenone|CS-W004082
      655-15-2

    References

    • US4436748 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H412
Precautionary Statements : P260-P264-P273-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.4033
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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