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Ethyl 2-amino-5-isopropylthiophene-3-carboxylate

  • CAS No. 65416-85-5

  • Cat. No. CS-0151808
  • Purity≥98%
  • MDL No.MFCD01922197

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-amino-5-isopropylthiophene-3-carboxylate|CS-0151808

Structure of 65416-85-5

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General Information

  • CAS No. 65416-85-5
  • Cat. No. CS-0151808
  • Purity ≥98%
  • MDL No. MFCD01922197
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅NO₂S
  • Molecular Weight 213.30
  • Synonym(s) ethyl 2-amino-5-propan-2-yl-thiophene-3-carboxylate
  • SMILES CCOC(=O)C1=C(N)SC(=C1)C(C)C

Description

Ethyl 2-amino-5-isopropylthiophene-3-carboxylate features a thiophene core with complementary electron-donating and steric modifiers. The para-amino group enables direct functionalization, while the isopropyl substituent enhances solubility and metabolic stability. This bench-stable intermediate supports efficient access to bioactive heterocycles in medicinal chemistry and materials science.

Application

Ethyl 2-amino-5-isopropylthiophene-3-carboxylate serves as a versatile building block in the synthesis of biologically relevant thiophene-based scaffolds. Its amino and ester functionalities enable straightforward derivatization via amidation, alkylation, and transition-metal-catalyzed coupling reactions. The isopropyl group enhances steric stability and solubility, while the molecule exhibits excellent bench stability and facilitates purification by standard chromatographic methods.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   2.6304
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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