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CS-W001157 4
Total: USD 88.00

4-(2-Aminoethyl)tetrahydropyran

  • CAS No. 65412-03-5

  • Cat. No. CS-W002907
  • Purity≥95%
  • MDL No.MFCD02179433

*For research and further manufacturing use only, not for direct human use.

4-(2-Aminoethyl)tetrahydropyran|CS-W002907

Structure of 65412-03-5

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General Information

  • CAS No. 65412-03-5
  • Cat. No. CS-W002907
  • Purity ≥95%
  • MDL No. MFCD02179433
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₅NO
  • Molecular Weight 129.20
  • Synonym(s) 2-(tetrahydro-2H-pyran-4-yl)ethanaminium
  • SMILES NCCC1CCOCC1

Description

4-(2-Aminoethyl)tetrahydropyran features a pendant amine group attached to a saturated pyran ring, offering enhanced solubility and nucleophilic reactivity. This scaffold integrates readily into bioconjugation workflows and serves as a versatile building block in medicinal chemistry, where the amine enables derivatization under mild conditions.

Application

4-(2-Aminoethyl)tetrahydropyran serves as a versatile scaffold for bioactive molecule synthesis, enabling efficient access to nitrogen-containing heterocycles. Its pendant amine facilitates conjugation and salt formation, while the tetrahydropyran ring offers metabolic stability and conformational restraint. The compound exhibits excellent bench stability and compatibility with standard coupling and reductive amination protocols, simplifying purification and integration into multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • US6368573 B1, ;
  • Route2

    References

    • Justus Liebigs Annalen der Chemie, , vol. 535, p. 37,45

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   0.7618
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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