Lot numbers can be found on the outside label of a product:
1,2-Oxazole-4-carbaldehyde
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CAS No. 65373-53-7
- Cat. No. CS-0071462
- Purity≥98%
- MDL No.MFCD02179515
*For research and further manufacturing use only, not for direct human use.
Structure of 65373-53-7
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General Information
- CAS No. 65373-53-7
- Cat. No. CS-0071462
- Purity ≥98%
- MDL No. MFCD02179515
- Storage 4°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₄H₃NO₂
- Molecular Weight 97.07
- Synonym(s) Isoxazole-4-carbaldehyde
- SMILES O=CC1=CON=C1
Description
1,2-Oxazole-4-carbaldehyde features a reactive aldehyde group fused to an electron-deficient oxazole ring, enabling direct coupling in heterocyclic synthesis. This bench-stable scaffold integrates readily into bioactive molecule design, offering high functional group tolerance and efficient access to complex nitrogen-containing architectures under standard conditions.
Application
1,2-Oxazole-4-carbaldehyde serves as a versatile synthon in heterocyclic synthesis, enabling direct functionalization at the C4 position via electrophilic or nucleophilic transformations. Its aldehyde group facilitates imine formation and reductive amination, while the oxazole ring provides stability and orthogonal reactivity. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it a practical building block for medicinal chemistry and API development.
Synthesis
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Route1
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In-stock
102790-36-3 - ~19%
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In-stock
65373-53-7
References
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AVEXA LIMITED Patent: WO2007/124546 A1, 2007 ; Location in patent: Page/Page column 61 ;
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Route2
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141679-66-5 - ~%
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In-stock
65373-53-7
References
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Taylor Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 1 p. 1 - 12
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Route3
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6455-40-9
- ~%
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In-stock
65373-53-7
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In-stock
6436-62-0
References
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Maggioni,P. et al. Gazzetta Chimica Italiana, 1966 , vol. 96, p. 443 - 453
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 43.1
- LogP 0.4871
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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