Lot numbers can be found on the outside label of a product:
2-Bromo-5-fluoro-3-nitropyridine
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CAS No. 652160-72-0
- Cat. No. CS-W005456
- Purity≥97%
- MDL No.MFCD05662387
*For research and further manufacturing use only, not for direct human use.
Structure of 652160-72-0
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General Information
- CAS No. 652160-72-0
- Cat. No. CS-W005456
- Purity ≥97%
- MDL No. MFCD05662387
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₂BrFN₂O₂
- Molecular Weight 220.98
- Synonym(s) 2-Bromo-5-fluoro-2-nitropyrdine
- SMILES O=[N+](C1=CC(F)=CN=C1Br)[O-]
Description
2-Bromo-5-fluoro-3-nitropyridine features a trifunctional pyridine core with bromo, fluoro, and nitro groups positioned for orthogonal reactivity. This electron-deficient heterocycle enables seamless coupling in cross-coupling and nucleophilic substitution workflows. The strategic substitution pattern supports modular synthesis of complex pharmaceutical intermediates under standard conditions.
Application
2-Bromo-5-fluoro-3-nitropyridine serves as a versatile building block in the synthesis of functionalized pyridine derivatives. Its orthogonal halogen (Br) and fluorine substituents enable sequential cross-coupling reactions, while the nitro group facilitates reduction and subsequent cyclization to access medicinally relevant heterocyclic scaffolds. The compound exhibits excellent bench stability and compatibility with standard Pd-catalyzed transformations, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.
Synthesis
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Route1
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In-stock
136888-20-5 - ~77%
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In-stock
652160-72-0
References
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Ueda, Yasutsugu; Connolly, Timothy P.; Kadow, John F.; Meanwell, Nicholas A.; Wang, Tao; Chen, Chung-Pin H.; Yeung, Kap-Sun; Zhang, Zhongxing; Leahy, David Kenneth; Pack, Shawn K.; Soundararajan, Nachimuthu; Sirard, Pierre; Levesque, Kathia; Thoraval, Dominique Patent: US2005/209246 A1, 2005 ; Location in patent: Page/Page column 31; 32 ;
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Route2
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In-stock
6628-77-9 - ~%
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In-stock
652160-72-0
References
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Journal of Medicinal Chemistry, , vol. 56, # 4 p. 1656 - 1669
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Route3
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In-stock
51173-04-7 - ~%
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In-stock
652160-72-0
References
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Journal of Medicinal Chemistry, , vol. 56, # 4 p. 1656 - 1669
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 56.03
- LogP 1.8914
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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