2-Chloro-4-methylnicotinonitrile

Name: 2-Chloro-4-methylnicotinonitrile
Brand: ChemScene
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CAS No. 65169-38-2
Cat. No. CS-0043657
Purity≥97%
MDL No.MFCD07082888

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-4-methylnicotinonitrile|CS-0043657

Structure of 65169-38-2

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Description

2-Chloro-4-methylnicotinonitrile features a sterically accessible nitrile group flanked by a chlorine substituent and a methyl moiety on the pyridine ring, enabling direct functionalization in late-stage diversification. This electron-deficient scaffold integrates readily into synthetic intermediates for pharmaceuticals and agrochemicals under standard conditions.

Application

2-Chloro-4-methylnicotinonitrile serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds via cross-coupling and nucleophilic substitution reactions. Its ortho-chloro and cyano groups provide complementary reactivity for late-stage functionalization, while the methyl group enhances metabolic stability. Bench-stable and amenable to purification by recrystallization or chromatography, it facilitates scalable synthesis of bioactive heterocycles.

General Information

CAS No. 65169-38-2
Cat. No. CS-0043657
Purity ≥97%
MDL No. MFCD07082888
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅ClN₂
Molecular Weight 152.58
Synonym(s) 3-Pyridinecarbonitrile, 2-chloro-4-methyl-
SMILES N#CC1=C(C)C=CN=C1Cl

Computational Chemistry Data

TPSA 36.68
LogP 1.9151
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-4-methylnicotinonitrile

CAS No. 65169-38-2

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