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3-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-1-ol

  • CAS No. 651030-57-8

  • Cat. No. CS-0096183
  • Purity≥97%
  • MDL No.MFCD18734359

*For research and further manufacturing use only, not for direct human use.

3-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-1-ol|CS-0096183

Structure of 651030-57-8

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General Information

  • CAS No. 651030-57-8
  • Cat. No. CS-0096183
  • Purity ≥97%
  • MDL No. MFCD18734359
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₃BO₃
  • Molecular Weight 262.15
  • Synonym(s) 4-Hydroxypropylphenylboronic acid pinacol ester
  • SMILES OCCCC1=CC=C(B2OC(C)(C)C(C)(C)O2)C=C1

Description

This boronate-functionalized propanol integrates readily into Suzuki-Miyaura coupling reactions, offering high stability and compatibility with diverse reaction conditions. The tetramethyl-1,3,2-dioxaborolane moiety enables efficient cross-coupling, while the terminal hydroxyl group provides a handle for further derivatization.

Synthesis

  • Route1

    References

    • MERCK and CO., INC. Patent: WO2008/51405 A1, 2008 ; Location in patent: Page/Page column 67 ; WO 2008/051405 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.69
  • LogP   1.9107
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   4

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