4-Chloro-2-methylquinazoline

Name: 4-Chloro-2-methylquinazoline
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CAS No. 6484-24-8
Cat. No. CS-W022143
Molecule weight178.62
Purity≥95%
MDL No.MFCD05666292

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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General Information

CAS No. 6484-24-8
Cat. No. CS-W022143
Purity ≥95%
MDL No. MFCD05666292
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₇ClN₂
Molecular Weight 178.62
Synonym(s) None
SMILES ClC1=NC(=NC2=CC=CC=C12)C

Description

4-Chloro-2-methylquinazoline is a heterocyclic scaffold featuring a chlorine atom at the 4-position and a methyl group at the 2-position, enabling selective functionalization in medicinal chemistry. This electron-deficient core integrates readily into kinase inhibitor architectures and serves as a key building block for bioactive molecules in drug discovery pipelines.

Application

4-Chloro-2-methylquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its chloro group at the 4-position exhibits high reactivity in Suzuki, Stille, and Buchwald–Hartwig transformations, while the 2-methyl substituent enhances solubility and modulates electronic properties. The scaffold is bench-stable, easily purified by recrystallization, and functions as a core motif in kinase inhibitor development and heterocyclic library synthesis.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 25.78
LogP 2.59162
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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4-Chloro-2-methylquinazoline

CAS No. 6484-24-8

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