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CS-W001157 4
Total: USD 88.00

1-Methyl-1,2-dihydroquinoxalin-2-one

  • CAS No. 6479-18-1

  • Cat. No. CS-0265478
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1,2-dihydroquinoxalin-2-one|CS-0265478

Structure of 6479-18-1

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General Information

  • CAS No. 6479-18-1
  • Cat. No. CS-0265478
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O
  • Molecular Weight 160.17
  • Synonym(s) 1-Methylquinoxalin-2-one
  • SMILES CN1C2=CC=CC=C2N=CC1=O

Description

1-Methyl-1,2-dihydroquinoxalin-2-one is a bench-stable heterocyclic scaffold featuring a fused quinoxaline core with a methylated nitrogen at the 1-position. This electron-deficient framework integrates readily into synthetic sequences requiring rigid, planar intermediates. The protected enolizable carbonyl site enables selective functionalization under mild conditions.

Application

1-Methyl-1,2-dihydroquinoxalin-2-one serves as a versatile scaffold in medicinal chemistry, enabling efficient access to quinoxaline-based heterocycles. Its stability under standard reaction conditions and tolerance to diverse functional groups facilitate downstream derivatization. The compound functions as a key building block for synthesizing fused polycyclic systems and is particularly valuable in the development of kinase inhibitors and other bioactive molecules through established coupling and cyclization protocols.

Synthesis

  • Route1
    • In-stock
      2-Quinoxalinol|CS-W018235
      1196-57-2
    • null|null
      74-88-4
    • ~82%
    • In-stock
      1-Methyl-1,2-dihydroquinoxalin-2-one|CS-0265478
      6479-18-1

    References

    • Maichrowski, Jan; Gjikaj, Mimoza; Huebner, Eike G.; Bergmann, Baerbel; Mueller, Ingrid B.; Kaufmann, Dieter E. European Journal of Organic Chemistry, 2013 , # 11 p. 2091 - 2105
  • Route2
    • null|null
      1029963-78-7
    • ~15%
    • In-stock
      1-Methyl-1,2-dihydroquinoxalin-2-one|CS-0265478
      6479-18-1
    • null|null
      93-61-8

    References

    • Bencivenni, Giorgio; Lanza, Tommaso; Leardini, Rino; Minozzi, Matteo; Nanni, Daniele; Spagnolo, Piero; Zanardi, Giuseppe Journal of Organic Chemistry, 2008 , vol. 73, # 12 p. 4721 - 4724
  • Route3
    • null|null
      1239573-75-1
    • ~86%
    • In-stock
      1-Methyl-1,2-dihydroquinoxalin-2-one|CS-0265478
      6479-18-1

    References

    • Chen, Dingben; Wang, Zhi-Jing; Bao, Weiliang Journal of Organic Chemistry, 2010 , vol. 75, # 16 p. 5768 - 5771

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   34.89
  • LogP   0.9335
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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