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CS-W001157 4
Total: USD 88.00

4-Methyl-1H-pyrazol-5-amine

  • CAS No. 64781-79-9

  • Cat. No. CS-0050811
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Methyl-1H-pyrazol-5-amine|CS-0050811

Structure of 64781-79-9

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General Information

  • CAS No. 64781-79-9
  • Cat. No. CS-0050811
  • Purity ≥96%
  • MDL No. None
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇N₃
  • Molecular Weight 97.12
  • Synonym(s) 4-methyl-1H-pyrazol-3-amine
  • SMILES CC1=C(N)NN=C1

Description

4-Methyl-1H-pyrazol-5-amine features a pyrazole core with a methyl group at the 4-position and an amine at the 5-position, delivering enhanced electron density for coupling reactions. This bench-stable scaffold integrates readily into bioactive molecules, offering improved solubility and reactivity in medicinal chemistry applications.

Application

4-Methyl-1H-pyrazol-5-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and cyclization reactions. Its pyrazole core exhibits good bench stability and functional group tolerance, facilitating straightforward derivatization for target-oriented synthesis. The molecule functions effectively in Pd-catalyzed cross-couplings and acts as a key scaffold in kinase inhibitor and antitumor agent development.

Synthesis

  • Route1
    • null|null
      63940-82-9
    • ~%
    • In-stock
      4-Methyl-1H-pyrazol-5-amine|CS-0050811
      64781-79-9

    References

    • EP1956009 A1, ; Page/Page column 90-91 ;
  • Route2
    • 2,3-Dibromo-2-methylpropanenitrile|CS-1149888
      28786-90-5
    • ~24%
    • In-stock
      4-Methyl-1H-pyrazol-5-amine|CS-0050811
      64781-79-9
    • 3,6-Dimethylpyrazolo[1,5-a]pyrimidin-7-amine|CS-0080921
      1431-00-1

    References

    • Journal of Heterocyclic Chemistry, , vol. 19, p. 1267 - 1273

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   0.30032
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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