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CS-W001157 4
Total: USD 88.00

Dicyclohexyl(phenyl)phosphine

  • CAS No. 6476-37-5

  • Cat. No. CS-0035166
  • Purity≥98%
  • MDL No.MFCD00003854

*For research and further manufacturing use only, not for direct human use.

Dicyclohexyl(phenyl)phosphine|CS-0035166

Structure of 6476-37-5

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General Information

  • CAS No. 6476-37-5
  • Cat. No. CS-0035166
  • Purity ≥98%
  • MDL No. MFCD00003854
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₂₇P
  • Molecular Weight 274.38
  • Synonym(s) Phenylphosphinodicyclohexane
  • SMILES C1(P(C2CCCCC2)C3CCCCC3)=CC=CC=C1

Description

Dicyclohexyl(phenyl)phosphine delivers robust ligand performance in palladium-catalyzed cross-coupling reactions. This sterically hindered phosphine features a phenyl group flanked by two cyclohexyl rings, enhancing stability and facilitating efficient catalyst activation under standard conditions.

Application

Dicyclohexyl(phenyl)phosphine serves as a robust, bench-stable ligand in palladium-catalyzed cross-coupling reactions. Its steric bulk and electron-rich character enhance catalyst activity and stability, particularly in Suzuki-Miyaura and Buchwald-Hartwig couplings. The ligand facilitates efficient C–C and C–N bond formation under mild conditions, with excellent functional group tolerance and ease of purification.

Synthesis

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    • In-stock
      Dicyclohexyl(phenyl)phosphine|CS-0035166
      6476-37-5

    References

    • Journal of the American Chemical Society, , vol. 128, # 13 p. 4240 - 4241
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    • In-stock
      Dicyclohexyl(phenyl)phosphine|CS-0035166
      6476-37-5

    References

    • Journal of the American Chemical Society, , vol. 102, # 10 p. 3350 - 3354
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    References

    • Journal of the Chemical Society, Chemical Communications, , # 8 p. 849 - 852

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   5.4592
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   3

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