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*For research and further manufacturing use only, not for direct human use.
Structure of 646502-53-6
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VcMMAE features a vinyl carbonate moiety paired with a maleimide group, enabling rapid, site-specific conjugation under physiological conditions. This bifunctional linker integrates seamlessly into antibody-drug conjugate workflows, delivering stable linkages with controlled payload release.
VcMMAE serves as a potent cytotoxic payload in antibody-drug conjugates, enabling targeted delivery to cancer cells. Its valine-citrulline linker provides protease-sensitive cleavage, ensuring controlled release within the intracellular environment. The maleimide moiety facilitates site-specific conjugation to cysteine residues on monoclonal antibodies. This combination offers high stability in circulation and efficient intracellular activation, making VcMMAE a well-established building block for next-generation biopharmaceuticals.
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GHS Pictogram :
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GHS No : GHS06,GHS08
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H300+H330-H340-H360-H370-H372-H412
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Precautionary Statements : P260-P264-P270-P271-P273-P280-P284-P304+P340-P330-P405-P501
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Lot numbers can be found on the outside label of a product: