Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

1-Tosylpyrrolidine

  • CAS No. 6435-78-5

  • Cat. No. CS-0197350
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Tosylpyrrolidine|CS-0197350

Structure of 6435-78-5

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 6435-78-5
  • Cat. No. CS-0197350
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅NO₂S
  • Molecular Weight 225.31
  • Synonym(s) 1-[(4-Methylphenyl)sulfonyl]pyrrolidine
  • SMILES CC1=CC=C(C=C1)S(=O)(=O)N2CCCC2

Description

1-Tosylpyrrolidine delivers a robust, bench-stable scaffold for asymmetric synthesis, featuring a sterically hindered pyrrolidine core and a para-tosyl group that enhances electrophilic reactivity. This combination enables efficient enantioselective transformations in catalytic systems.

Application

1-Tosylpyrrolidine serves as a robust chiral auxiliary and nitrogen protecting group in asymmetric synthesis, enabling stereoselective transformations through well-documented enolate chemistry. Its tosyl moiety provides excellent stability under basic conditions and facilitates easy removal via nucleophilic cleavage. The compound functions effectively in aldol, alkylation, and Mannich reactions, offering predictable stereocontrol and clean purification profiles.

Synthesis

  • Route1
    • null|null
      57671-12-2
    • ~78%
    • In-stock
      1-Tosylpyrrolidine|CS-0197350
      6435-78-5

    References

    • Garcia Ruano, Jose L.; Parra, Alejandro; Marzo, Leyre; Yuste, Francisco; Mastranzo, Virginia M. Tetrahedron, 2011 , vol. 67, # 16 p. 2905 - 2910
  • Route2

    References

    • Lee, Sujin; Shin, Ju Yeon; Lee, Sang-Gi Chemistry - An Asian Journal, 2013 , vol. 8, # 9 p. 1990 - 1993
  • Route3
    • null|null
      109-99-9
    • In-stock
      p-Toluenesulfonamide|CS-0012133
      70-55-3
    • ~10%
    • In-stock
      1-Tosylpyrrolidine|CS-0197350
      6435-78-5

    References

    • Shi, Wei; Bai, Chun-Mei; Zhu, Kai; Cui, Dong-Mei; Zhang, Chen Tetrahedron, 2014 , vol. 70, # 2 p. 434 - 438

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   37.38
  • LogP   1.77952
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 1-Tosylpyrrolidine sigma1-Tosylpyrrolidine manufacturer1-Tosylpyrrolidine price1-Tosylpyrrolidine structure1-Tosylpyrrolidine SDSbuy 1-Tosylpyrrolidine1-Tosylpyrrolidine supplier1-Tosylpyrrolidine uses1-Tosylpyrrolidine molecular weightprice of 1-Tosylpyrrolidine1-Tosylpyrrolidine chemical name formula of 1-Tosylpyrrolidine
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label