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CS-W001157 4
Total: USD 88.00

4-(Hydroxymethyl)pyrrolidin-2-one

  • CAS No. 64320-89-4

  • Cat. No. CS-0046664
  • Purity≥95%
  • MDL No.MFCD11845728

*For research and further manufacturing use only, not for direct human use.

4-(Hydroxymethyl)pyrrolidin-2-one|CS-0046664

Structure of 64320-89-4

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General Information

  • CAS No. 64320-89-4
  • Cat. No. CS-0046664
  • Purity ≥95%
  • MDL No. MFCD11845728
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉NO₂
  • Molecular Weight 115.13
  • Synonym(s) 4-(Hydroxymethyl)-2-pyrrolidinone
  • SMILES O=C1CC(CO)CN1

Description

4-(Hydroxymethyl)pyrrolidin-2-one is a bench-stable, moisture-tolerant heterocyclic scaffold featuring a pendant hydroxymethyl group. This functionalized pyrrolidinone integrates readily into synthetic routes requiring polar, hydrogen-bonding handles. The molecule’s balanced solubility and stability simplify handling in aqueous and organic media, enabling efficient derivatization for medicinal chemistry applications.

Application

4-(Hydroxymethyl)pyrrolidin-2-one serves as a versatile scaffold in medicinal chemistry, enabling efficient access to diverse heterocyclic systems. Its pendant hydroxymethyl group facilitates selective derivatization via oxidation, protection, or coupling reactions, while the pyrrolidinone core offers excellent solubility and metabolic stability. The compound exhibits robust bench stability and is compatible with standard synthetic protocols, making it a practical building block for API development and library synthesis.

Synthesis

  • Route1
    • null|null
      183062-94-4
    • ~59%
    • In-stock
      4-(Hydroxymethyl)pyrrolidin-2-one|CS-0046664
      64320-89-4

    References

    • Carruthers, Nicholas I.; Wong, Shing-Chun; Chan, Tze-Ming Journal of Chemical Research - Part S, 1996 , # 9 p. 430 - 431
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 1 p. 380 - 382
  • Route3
    • null|null
      183062-93-3
    • ~%
    • In-stock
      4-(Hydroxymethyl)pyrrolidin-2-one|CS-0046664
      64320-89-4

    References

    • Journal of Chemical Research - Part S, , # 9 p. 430 - 431

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS08,GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H319-H372-H411
Precautionary Statements : P260-P264-P270-P273-P280-P330-P391-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   -0.8852
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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